• Early diagnosis of mild cognitive impairment (MCI) is important, because some cases can progress to Alzheimer’s disease.
• Early diagnosis is done through a combination of cognitive testing, imaging, and laboratory tests.
• There are steps you can take after an early diagnosis, such as exercise, that can slow the progression of MCI.

Memory declines with age — things that were once crisp and clear in the mind when you were younger are probably a little foggier now. A certain amount of forgetfulness is normal as we age. However, if you or a loved one is experiencing memory problems that seem to be out of the norm, it may be a condition called mild cognitive impairment.

MCI is an “in-between stage between normal aging and dementia,” explained Dr. Jennifer Davis, a clinical neuropsychologist at Brown University in Rhode Island. Dr. Davis specializes in Alzheimer’s disease and related conditions.

Not all cases of mild cognitive impairment progress to dementia, but MCI can sometimes be caused by the same underlying problems that lead to Alzheimer’s disease and dementia with Lewy bodies. An estimated 6 percent of individuals aged 60 and older have MCI. Read more about MCI.

All of the following symptoms are associated with MCI:

	Increased forgetfulness
	Problems in cognitive function (making decisions or planning)
	Difficulty understanding instructions
	Getting lost in familiar places
	Increased agitation
	Increased impulsivity
	Increased irritability
	Sleep problems
	Anxiety
	Depression

It is important to diagnose MCI as early as possible because some cases of MCI may progress to Alzheimer’s disease. There are benefits of early diagnosis, including slowing the progression of memory impairment and saving health care costs.

How Is MCI Diagnosed?

The diagnosis of mild cognitive impairment usually starts when family or friends begin to notice that their loved one is becoming more forgetful, getting lost, or experiencing other symptoms of memory loss.

“We all have certain memory lapses, but when you're starting to see that pattern and that recurrence, that’s when you want to get it checked out,” Dr. Davis said. Acknowledging these memory changes can pave the way to an early diagnosis.

Health care providers can use a variety of tests to help determine if someone has MCI. Initially, a doctor might:

	Conduct an interview to determine the impact symptoms have had on daily life.
	Determine whether family members and friends have noticed any changes.
	Test memory abilities using a cognitive test, such as the Montreal Cognitive Assessment.
	Conduct blood tests to rule out other health conditions.

If your primary care doctor suspects MCI, they will usually recommend you see a specialist, such as a neuropsychologist. The specialist will likely want to order some brain imaging tests to investigate a possible case of MCI.

Tests for MCI

You may undergo imaging tests and blood or spinal fluid tests if your doctor suspects MCI. Your doctor may order a [¹⁸F]fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging test. This test has been scientifically shown to help identify MCI.

You may also undergo magnetic resonance imaging (MRI). Research shows that combining information from an MRI scan with a PET scan can also identify MCI. Follow-up appointments may be necessary in order to reach a diagnosis.

Since some cases of MCI can develop into Alzheimer’s, a blood or spinal fluid test that identifies biomarkers associated with Alzheimer’s may sometimes be conducted as well.

Research To Improve Early Diagnosis

Research into the underlying biological causes of MCI will help improve the ability to diagnose it. Scientists have identified several physical brain changes associated with MCI, such as:

	The accumulation of beta-amyloid proteins
	Tau proteins
	Lewy bodies
	Enlarged ventricles (cavities in the brain filled with cerebrospinal fluid)
	Shrinkage of the hippocampus (a part of the brain critical for memory)

Benefits of Early Diagnosis

Early diagnosis of mild cognitive impairment is very important, since some cases of MCI may progress to Alzheimer’s. However, not everyone diagnosed with MCI is likely to develop Alzheimer’s disease.

One study of 1,208 people with MCI found that, after two years, 14 percent of participants had reverted back to normal cognition, 51 percent stayed about the same, and 35 percent progressed to dementia. Another research study of over 18,000 people aged 65 or older suggested that the proportion of individuals who progress from MCI to Alzheimer’s is closer to 22 percent.

Early diagnosis and intervention is important for several reasons. First, if someone is diagnosed early, their level of function has the potential to be preserved for a longer period. Additionally, early diagnosis can mean lower health care costs.

Steps To Improve Memory Health

The sooner a clinical diagnosis of MCI is confirmed, the sooner proactive steps can be taken to slow MCI progression and declines in cognitive ability. “As soon as you can understand what you're experiencing, most people find a sense of relief. You have something you can focus on,” Dr. Davis said.

Currently, there aren’t any drugs that have been approved by the U.S. Food and Drug Administration (FDA) to treat mild cognitive impairment. However, there are things that can be done to help slow the progression of MCI after an early diagnosis. Some of these include:

	Memory training exercises
	Changes in diet
	Aerobic exercise
	Foreign language study
	Taking certain vitamins

Always consult a doctor before taking new supplements or making significant changes to diet or exercise. Learn more about tips to improve your memory health.

Planning Ahead

The primary benefit of early MCI diagnosis is that it helps identify individuals who are most at risk for dementia. Once a diagnosis is made, a person can get advice, support, and information about what MCI is and how it can lead to Alzheimer’s.

Early diagnosis gives people time to plan ahead. Although diagnosing MCI isn’t always easy, it is important to diagnose as soon as possible to identify any risk for Alzheimer’s and other forms of dementia.

Finding Support for Mild Cognitive Impairment

“When someone is diagnosed with MCI, people feel they've failed in some way, that they're not intelligent, that they're not as useful,” Dr. Davis said. “And certainly that's not the case.”

If you or a loved one has MCI, you are not alone. Nearly 74,000 myALZteam members can relate to your experience. Memory problems, including MCI, are not uncommon in older adults. Thankfully, there are support systems available to help you deal with your diagnosis and continue to have a fulfilling life. Support is available for caregivers too.

Have you been diagnosed with mild cognitive impairment? What was your diagnostic process like? Share your experiences in the comments below or on myALZteam.

References

1. The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: The COSMIC collaboration — PLOS One
2. Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction — International Journal of Geriatric Psychiatry
3. Early Diagnosis of Alzheimer’s Disease: Is MCI Too Late? — Current Alzheimer Research
4. Relationship between the Montreal Cognitive Assessment and Mini-mental State Examination for assessment of mild cognitive impairment in older adults — BMC Geriatrics
5. Clinical utility of FDG-PET for the clinical diagnosis in MCI — European Journal of Nuclear Medicine and Molecular Imaging
6. Hierarchical Feature Representation and Multimodal Fusion with Deep Learning for AD/MCI Diagnosis — Neuroimage
7. Supporting evidence for using biomarkers in the diagnosis of MCI due to AD — Journal of Neurology
8. State of the science on mild cognitive impairment (MCI) — CNS Spectrums
9. Predictors of Reversion from Mild Cognitive Impairment to Normal Cognition — Dementia and Geriatric Cognitive Disorders
10. Estimating Alzheimer's Disease Progression Rates from Normal Cognition Through Mild Cognitive Impairment and Stages of Dementia — Current Alzheimer Research
11. Early diagnosis of Alzheimer's disease: clinical and economic benefits — Journal of the American Geriatrics Society
12. Cognitive Training Program to Improve Working Memory in Older Adults with MCI — Clinical Gerontologist
13. Dietary ketosis enhances memory in mild cognitive impairment — Neurobiology of Aging
14. Effects of a moderate-intensity aerobic exercise programme on the cognitive function and quality of life of community-dwelling elderly people with mild cognitive impairment: A randomised controlled trial — International Journal of Nursing Studies
15. Foreign language learning as potential treatment for mild cognitive impairment — Hong Kong Medical Journal
16. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design — Current Alzheimer Research