Calling in the middle of the night indicates she is having trouble sleeping through the night. When she wakes up, she is probably a little confused about whether it is an appropriate to get up and start her day. Definitely need to review the nighttime routine. My sister quickly transitioned from sleeping 9 hours at night, to waking every 2 - 3 hours and wandering around the house. Supervision is critical at that point.

You need to talk with your physician about meds for night time to assist with sleep. Tight now my mom is using Serriqill and trazadone to help go to sleep. Ask your doctor what would be good for her.

Margaret's sleep pattern has deteriorated to the point where she would barely sleep for 3 or 4 days at a time and as she is a wanderer it became very hard to manage. I resorted to giving her sleeping tablets. If she is calm when she takes them she will sleep for between 6 and 10 hours but if she is agitated they have no impact at all. It was a last resort but I'm glad we went for it as it means she can stay at home

You could ask your doctor what there might be in the way of overnight supports in your area. It may be time she shouldn't be left alone.